INCREDB ID : 456
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Anjali A. Karande, Ph.D.
Professor 
 
Indian Institute of Science
CV Raman Road
Banglore - 560 012   
Karnataka   
 
E-mail: anjali@biochem.iisc.ernet.in
 
URL: http://biochem.iisc.ernet.in/anjali%20a%20k.htm
 
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellowship 1977-1979
 
Research Summary:
Immuno-endocrinology
 
Publications:
1.Chakravarthi, B. V., Sujay, R., Kuriakose, G. C., Karande, A. A. and Jayabaskaran, C.  Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani. Cancer Cell International. 2013.  13, 105. [PubMed]
2.Bagaria, S., Ponnalagu, D., Bisht, S. and Karande, A. A.  Mechanistic insights into the neutralization of cytotoxic abrin by the monoclonal antibody D6F10. PloS One. 2013.  8, e70273. [PubMed]
3.Goswami, T. K., Gadadhar, S., Gole, B., Karande, A. A. and Chakravarty, A. R.  Photocytotoxicity of copper(II) complexes of curcumin and N-ferrocenylmethyl-L-amino acids. European Journal of Medicinal Chemistry. 2013.  63, 800-810. [PubMed]
4.Gadadhar, S. and Karande, A. A.  Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway. PloS One. 2013.  8, e58304. [PubMed]
5.Ponnalagu, D. and Karande, A. A.  Mapping the apoptosis inducing domain of an immunomodulatory protein: glycodelin A. Molecular and Cellular Biochemistry. 2013.  377, 131-141. [PubMed]
6.Das, S., Shetty, R. K., Kumar, A., Shridharan, R. N., Tatineni, R., Chi, G., Mukherjee, A., Das, S., Subbarao, S. M. and Karande, A. A.  Monoclonal antibodies against Hepatitis C genotype 3a virus like particle inhibit virus entry in cell culture system. PloS One. 2013.  8, e53619. [PubMed]
7.Maity, B., Gadadhar, S., Goswami, T. K., Karande, A. A. and Chakravarty, A. R.  Photo-induced anticancer activity of polypyridyl platinum(II) complexes. European Journal of Medicinal Chemistry. 2012.  57, 250-258. [PubMed]
8.Anbu, S., Shanmugaraju, S., Ravishankaran, R., Karande, A. A. and Mukherjee, P. S.  Naphthylhydrazone based selective and sensitive chemosensors for Cu2+ and their application in bioimaging. Dalton Transactions. 2012.  41, 13330-13337. [PubMed]
9.Anbu, S., Ravishankaran, R., Karande, A. A. and Kandaswamy, M.  DNA targeting polyaza macrobicyclic dizinc(II) complexes promoting high in vitro caspase dependent anti-proliferative activity against human carcinoma cancer cells. Dalton Transactions. 2012.  41, 12970-12983. [PubMed]
10.Manohar, M., Hirsh, M. I., Chen, Y., Woehrle, T., Karande, A. A. and Junger, W. G.  ATP release and autocrine signaling through P2X4 receptors regulate gammadelta T cell activation. Journal of Leukocyte Biology. 2012.  92, 787-794. [PubMed]
11.Hussain, A., Gadadhar, S., Goswami, T. K., Karande, A. A. and Chakravarty, A. R.  Photoactivated DNA cleavage and anticancer activity of pyrenyl-terpyridine lanthanide complexes. European Journal of Medicinal Chemistry. 2012.  50, 319-331. [PubMed]
12.Soni, C. and Karande, A. A.  Glycodelin-A interferes with IL-2/IL-2R signalling to induce cell growth arrest, loss of effector functions and apoptosis in T-lymphocytes. Human Reproduction. 2012.  27, 1005-1015. [PubMed]
13.Chiruvella, K. K., Sebastian, R., Sharma, S., Karande, A. A., Choudhary, B. and Raghavan, S. C.  Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice. Journal of Molecular Biology. 2012.  417, 197-211. [PubMed]
14.Choudhary, B., Karande, A. A. and Raghavan, S. C.  Telomere and telomerase in stem cells: relevance in ageing and disease. Frontiers in Bioscience. 2012.  4, 16-30. [PubMed]
15.Hussain, A., Gadadhar, S., Goswami, T. K., Karande, A. A. and Chakravarty, A. R.  Photo-induced DNA cleavage activity and remarkable photocytotoxicity of lanthanide(III) complexes of a polypyridyl ligand. Dalton Transactions. 2012.  41, 885-895. [PubMed]
16.Maity, B., Gadadhar, S., Goswami, T. K., Karande, A. A. and Chakravarty, A. R.  Impact of metal on the DNA photocleavage activity and cytotoxicity of ferrocenyl terpyridine 3d metal complexes. Dalton Transactions. 2011.  40, 11904-11913. [PubMed]
17.Goswami, T. K., Chakravarthi, B. V., Roy, M., Karande, A. A. and Chakravarty, A. R.  Ferrocene-conjugated L-tryptophan copper(II) complexes of phenanthroline bases showing DNA photocleavage activity and cytotoxicity. Inorganic Chemistry. 2011.  50, 8452-8464. [PubMed]
18.Pandey, V., Madhumathi, J., Karande, A. A. and Kaliraj, P.  Antigen detection assay with parasite specific monoclonal antibodies for diagnosis of lymphatic filariasis. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2011.  412, 1867-1873. [PubMed]
19.Roy, M., Chakravarthi, B. V., Jayabaskaran, C., Karande, A. A. and Chakravarty, A. R.  Impact of metal binding on the antitumor activity and cellular imaging of a metal chelator cationic imidazopyridine derivative. Dalton Transactions. 2011.  40, 4855-4864. [PubMed]
20.Jain, E., Karande, A. A. and Kumar, A.  Supermacroporous polymer-based cryogel bioreactor for monoclonal antibody production in continuous culture using hybridoma cells. Biotechnology Progress. 2011.  27, 170-180. [PubMed]
21.Bora, N., Gadadhar, S. and Karande, A. A.  Signaling different pathways of cell death: Abrin induced programmed necrosis in U266B1 cells. The International Journal of Biochemistry & Cell Biology. 2010.  42, 1993-2003. [PubMed]
22.Soni, C. and Karande, A. A.  Glycodelin A suppresses the cytolytic activity of CD8+ T lymphocytes. Molecular Immunology. 2010.  47, 2458-2466. [PubMed]
23.Alok, A. and Karande, A. A.  The role of glycodelin as an immune-modulating agent at the feto-maternal interface. Journal of Reproductive Immunology. 2009.  83, 124-127. [PubMed]
24.SundarRaj, S., Soni, C. and Karande, A. A.  Glycodelin A triggers T cell apoptosis through a novel calcium-independent galactose-binding lectin activity. Molecular Immunology. 2009.  46, 3411-3419. [PubMed]
25.Johnson, T., Ouhtit, A., Gaur, R., Fernando, A., Schwarzenberger, P., Su, J., Ismail, M. F., El-Sayyad, H. I., Karande, A., Elmageed, Z. A., Rao, P. and Raj, M.  Biochemical characterization of riboflavin carrier protein (RCP) in prostate cancer. Frontiers in Bioscience. 2009.  14, 3634-3640. [PubMed]
26.Alok, A., Mukhopadhyay, D. and Karande, A. A.  Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells. The International Journal of Biochemistry & Cell Biology. 2009.  41, 1138-1147. [PubMed]
27.Chakravarthi, B. V., Das, P., Surendranath, K., Karande, A. A. and Jayabaskaran, C.  Production of paclitaxel by Fusarium solani isolated from Taxus celebica. Journal of Biosciences. 2008.  33, 259-267. [PubMed]
28.Surendranath, K. and Karande, A. A.  A neutralizing antibody to the a chain of abrin inhibits abrin toxicity both in vitro and in vivo. Clinical and Vaccine Immunology : CVI. 2008.  15, 737-743. [PubMed]
29.SundarRaj, S., Mukhopadhyay, D. and Karande, A. A.  Glycodelin A triggers mitochondrial stress and apoptosis in T cells by a mechanism distinct and independent of TCR signaling. Molecular Immunology. 2008.  45, 2391-2400. [PubMed]
30.Bangaru, M. L. and Karande, A. A.  Biochemical characterization of recombinant chicken Riboflavin carrier protein. Molecular and Cellular Biochemistry. 2008.  308, 1-7. [PubMed]
31.Poornima, B. L. and Karande, A. A.  Differential sialylation regulates the apoptotic activity of glycodelin A. FEBS Letters. 2007.  581, 4366-4370. [PubMed]
32.Wilson, A. C., Salamat, M. S., Haasl, R. J., Roche, K. M., Karande, A., Meethal, S. V., Terasawa, E., Bowen, R. L. and Atwood, C. S.  Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression. The Journal of Endocrinology. 2006.  191, 651-663. [PubMed]
33.Jayachandran, R., Radcliffe, C. M., Royle, L., Harvey, D. J., Dwek, R. A., Rudd, P. M. and Karande, A. A.  Oligosaccharides modulate the apoptotic activity of glycodelin. Glycobiology. 2006.  16, 1052-1063. [PubMed]
34.Bagaria, A., Surendranath, K., Ramagopal, U. A., Ramakumar, S. and Karande, A. A.  Structure-function analysis and insights into the reduced toxicity of Abrus precatorius agglutinin I in relation to abrin. The Journal of Biological Chemistry. 2006.  281, 34465-34474. [PubMed]
35.Karande, A. A., Mukhopadhyay, D., Jayachandran, R., Sundarraj, S. and Alok, A.  Mechanism of the immunomodulatory activity of glycodelin. Indian Journal of Physiology and Pharmacology. 2005.  49, 271-283. [PubMed]
36.Narayanan, S., Surendranath, K., Bora, N., Surolia, A. and Karande, A. A.  Ribosome inactivating proteins and apoptosis. FEBS Letters. 2005.  579, 1324-1331. [PubMed]
37.Karande A.  Eppin: a candidate male contraceptive vaccine? Journal of Biosciences. 2004.  29, 373-374. [PubMed]
38.Muralikrishna, B., Thanumalayan, S., Jagatheesan, G., Rangaraj, N., Karande, A. A. and Parnaik, V. K.  Immunolocalization of detergent-susceptible nucleoplasmic lamin A/C foci by a novel monoclonal antibody. Journal of Cellular Biochemistry. 2004.  91, 730-739. [PubMed]
39.Mukhopadhyay, D., SundarRaj, S., Alok, A. and Karande, A. A.  Glycodelin A, not glycodelin S, is apoptotically active. Relevance of sialic acid modification. The Journal of Biological Chemistry. 2004.  279, 8577-8584. [PubMed]
40.Jayachandran, R., Shaila, M. S. and Karande, A. A.  Analysis of the role of oligosaccharides in the apoptotic activity of glycodelin A. The Journal of Biological Chemistry. 2004.  279, 8585-8591. [PubMed]
41.Subramanian, S., Andal, S., Karande, A. A. and Radhakantha, A.  Epitope mapping and evaluation of specificity of T-helper sites in four major antigenic peptides of chicken riboflavin carrier protein in outbred rats. Biochemical and Biophysical Research Communications. 2003.  311, 11-16. [PubMed]
42.Narayanan, S., Surolia, A. and Karande, A. A.  Ribosome-inactivating protein and apoptosis: abrin causes cell death via mitochondrial pathway in Jurkat cells. The Biochemical Journal. 2004.  377, 233-240. [PubMed]
43.Gangatirkar, P., Gangadharan, S., Narendranath, A., Nagpal, S., Salunke, D. M. and Karande, A. A.  Monoclonal antibodies to gonadotropin-releasing hormone (GnRH) inhibit binding of the hormone to its receptor. Hybridoma and Hybridomics. 2002.  21, 281-286. [PubMed]
44.Mitra-Kaushik, S., Shaila, M. S., Karande, A. and Nayak, R.  Idiotype and anti-idiotype specific T cell responses on transplantation with hybridomas reactive to viral hemagglutinin and human tumor antigen. Immunology Letters. 2002.  80, 81-87. [PubMed]
 
Education 
::
Ph.D.
  Last modified on : Dec 6, 2013
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