Padma Shastry, Ph.D.
National Centre for Cell Science
NCCS Complex, Pune University Campus
Ganeshkhind
Pune - 411 007
Maharashtra
E-mail: padma@nccs.res.in
Phone: +91-020-25708108
Fax: +91-020-25692259
URL: http://www.nccs.res.in/pshastry.html
Research Summary:
Mechanisms of drug resistance and sensitivity in gliomas using monolayers (2D) and multicellular spheroids (MCS) cultured cells
Publications:
1.
Pujari, R., Eligar, S. M., Kumar, N., Barkeer, S., Reddy, V., Swamy, B. M., Inamdar, S. R. and Shastry, P. Rhizoctonia Bataticola Lectin (RBL) Induces Caspase-8-Mediated Apoptosis in Human T-Cell Leukemia Cell Lines but Not in Normal CD3 and CD34 Positive Cells. PloS One. 2013. 8, e79311. [PubMed]
2.
Shah, R. D., Jagtap, J. C., Mruthyunjaya, S., Shelke, G. V., Pujari, R., Das, G. and Shastry, P. Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. Journal of Cellular Biochemistry. 2013. 114, 854-863. [PubMed]
3.
Londhe, J. S., Devasagayam, T. P., Foo, L. Y., Shastry, P. and Ghaskadbi, S. S. Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity. Fitoterapia. 2012. 83, 1562-1568. [PubMed]
4.
Inamdar, S. R., Savanur, M. A., Eligar, S. M., Chachadi, V. B., Nagre, N. N., Chen, C., Barclays, M., Ingle, A., Mahajan, P., Borges, A., Shastry, P., Kalraiya, R. D., Swamy, B. M., Rhodes, J. M. and Yu, L. G. The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo. Glycobiology. 2012. 22, 1227-1235. [PubMed]
5.
Pujari, R., Eligar, S. M., Kumar, N., Nagre, N. N., Inamdar, S. R., Swamy, B. M. and Shastry, P. CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin (RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC. Biochemical and Biophysical Research Communications. 2012. 419, 708-714. [PubMed]
6.
Lokwani, D., Shah, R., Mokale, S., Shastry, P. and Shinde, D. Development of energetic pharmacophore for the designing of 1,2,3,4-tetrahydropyrimidine derivatives as selective cyclooxygenase-2 inhibitors. Journal of Computer-aided Molecular Design. 2012. 26, 267-277. [PubMed]
7.
Mruthyunjaya, S., Rumma, M., Ravibhushan, G., Anjali, S. and Padma, S. c-Jun/AP-1 transcription factor regulates laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells: role of multiple signaling pathways. FEBS Letters. 2011. 585, 1915-1922. [PubMed]
8.
Das, G., Shiras, A., Shanmuganandam, K. and Shastry, P. Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells. Molecular Carcinogenesis. 2011. 50, 412-423. [PubMed]
9.
Kale, A., Kale, S., Yadav, P., Gholap, H., Pasricha, R., Jog, J. P., Lefez, B., Hannoyer, B., Shastry, P. and Ogale, S. Magnetite/CdTe magnetic-fluorescent composite nanosystem for magnetic separation and bio-imaging. Nanotechnology. 2011. 22, 225101. [PubMed]
10.
Nagre, N. N., Chachadi, V. B., Eligar, S. M., Shubhada, C., Pujari, R., Shastry, P., Swamy, B. M. and Inamdar, S. R. Purification and characterization of a mitogenic lectin from cephalosporium, a pathogenic fungus causing mycotic keratitis. Biochemistry Research International. 2010. 2010, 854656. [PubMed]
11.
Pujari, R., Nagre, N. N., Chachadi, V. B., Inamdar, S. R., Swamy, B. M. and Shastry, P. Rhizoctonia bataticola lectin (RBL) induces mitogenesis and cytokine production in human PBMC via p38 MAPK and STAT-5 signaling pathways. Biochimica et Biophysica Acta. 2010. 1800, 1268-1275. [PubMed]
12.
Nagre, N. N., Chachadi, V. B., Sundaram, P. M., Naik, R. S., Pujari, R., Shastry, P., Swamy, B. M. and Inamdar, S. R. A potent mitogenic lectin from the mycelia of a phytopathogenic fungus, Rhizoctonia bataticola, with complex sugar specificity and cytotoxic effect on human ovarian cancer cells. Glycoconjugate Journal. 2010. 27, 375-386. [PubMed]
13.
Mruthyunjaya, S., Manchanda, R., Godbole, R., Pujari, R., Shiras, A. and Shastry, P. Laminin-1 induces neurite outgrowth in human mesenchymal stem cells in serum/differentiation factors-free conditions through activation of FAK-MEK/ERK signaling pathways. Biochemical and Biophysical Research Communications. 2010. 391, 43-48. [PubMed]
14.
Sudheerkumar, P., Shiras, A., Das, G., Jagtap, J. C., Prasad, V. and Shastry, P. Independent activation of Akt and NF-kappaB pathways and their role in resistance to TNF-alpha mediated cytotoxicity in gliomas. Molecular Carcinogenesis. 2008. 47, 126-136. [PubMed]
15.
Kumar, P. S., Shiras, A., Das, G., Jagtap, J. C., Prasad, V. and Shastry, P. Differential expression and role of p21cip/waf1 and p27kip1 in TNF-alpha-induced inhibition of proliferation in human glioma cells. Molecular Cancer. 2007. 6, 42. [PubMed]
16.
Shiras, A., Chettiar, S. T., Shepal, V., Rajendran, G., Prasad, G. R. and Shastry, P. Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells. 2007. 25, 1478-1489. [PubMed]
17.
Prasad, V., Chandele, A., Jagtap, J. C., Sudheer, K. and Shastry, P. ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis. Free Radical Biology & Medicine. 2006. 41, 431-442. [PubMed]
18.
Deshpande, P. and Shastry, P. Modulation of cytokine profiles by malaria pigment--hemozoin: role of IL-10 in suppression of proliferative responses of mitogen stimulated human PBMC. Cytokine. 2004. 28, 205-213. [PubMed]
19.
Chandele, A., Prasad, V., Jagtap, J. C., Shukla, R. and Shastry, P. R. Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis. Neoplasia. 2004. 6, 29-40. [PubMed]
20.
Shiras, A., Bhosale, A., Shepal, V., Shukla, R., Baburao, V. S., Prabhakara, K. and Shastry, P. A unique model system for tumor progression in GBM comprising two developed human neuro-epithelial cell lines with differential transforming potential and coexpressing neuronal and glial markers. Neoplasia. 2003. 5, 520-532. [PubMed]
21.
Jagtap, J. C., Chandele, A., Chopde, B. A. and Shastry, P. Sodium pyruvate protects against H(2)O(2) mediated apoptosis in human neuroblastoma cell line-SK-N-MC. Journal of Chemical Neuroanatomy. 2003. 26, 109-118. [PubMed]
22.
Mahajan, R. G., Patil, S. I., Mohan, D. R. and Shastry, P. Pleurotus Eous mushroom lectin (PEL) with mixed carbohydrate inhibition and antiproliferative activity on tumor cell lines. Journal of Biochemistry, Molecular Biology, and Biophysics : JBMBB : the Official Journal of the Federation of Asian and Oceanian Biochemists and Molecular. 2002. 6, 341-345. [PubMed]
23.
Shiras, A., Bhosale, A., Patekar, A., Shepal, V. and Shastry, P. Differential expression of CD44(S) and variant isoforms v3, v10 in three-dimensional cultures of mouse melanoma cell lines. Clinical & Experimental Metastasis. 2002. 19, 445-455. [PubMed]
24.
Jacob, S. S., Shastry, P. and Sudhakaran, P. R. Monocyte-macrophage differentiation in vitro: modulation by extracellular matrix protein substratum. Molecular and Cellular Biochemistry. 2002. 233, 9-17. [PubMed]
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of Prostrate Apoptosis Response-4 (Par-4 )and its interactive proteins in chemo resistance/ sensitivity in gliomas using multi-cellular spheroids (MCS) as model
Principal Investigator
Indian Council of Medical Research, Government of India
2010-2013
Exploring the potential of Tf antigen binding property of lectin from sclerotium rolfsii for anticancer effect
Department of Biotechnology, Government of India
2010-2013
Differentiation of human Mesenchymal stem cells (MSC) towards neuronal lineages
Department of Biotechnology, Government of India
2005-2008
Last modified on : Dec 9, 2015