INCREDB ID : 223
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Gaurisankar Sa, Ph.D.
Professor 
 
Bose Institute
Division of Molecular Medicine
P 1/12, C. I. T. Road, Scheme - VIIM
Kolkata - 700 054    
West Bengal   
 
E-mail: gauri@ boseinst.ernet.in, gaurisankarsa@yahoo.com
Phone: +91-33-2569 3258
Fax: + 91-33-2355 3886
 
URL: http://bic.boseinst.ernet.in/gauri/
 
Positions Held:
Position Affiliation Time Period
Professor Bose Institute, Kolkata, India
 
Area of Specialization:
Cancer Biology
Tumor Immunology
Research Summary:
Understanding the mechanisms of cell cycle regulation in normal and malignant cells
Molecular understanding of the role of oncogenic Ras in cancer progression and regression
Targeted alteration of signaling molecules to selectively induce apoptosis in cancer cells
Cell cycle phase specific p53 stabilization in normal and malignant cells
Molecular engineering-based therapeutic strategy to regain pro-apoptotic program of cancer cells
Development of anti-cancer drug from natural sources
Genomic and proteomic and system biology analysis to target cancer-specific genes
Immune evasion by tumors: Immune editing to rejuvenate tumor-induced immunosuppression
Molecular understanding of the mechanisms of tumor-induced type-2 cytokine bias
Role of T-regulatory cells in immune evasion
Involvement of stromal cells in tumor-induced immune dysfunction
 
Publications:
1. Chakraborty, J., Banerjee, S., Ray, P., Hossain, D. M., Bhattacharyya, S., Adhikary, A., Chattopadhyay, S., Das, T. and Sa, G.  Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells. The Journal of Biological Chemistry. 2010.  285, 33104-33112. [PubMed]
2. Lahiry, L., Saha, B., Chakraborty, J., Adhikary, A., Mohanty, S., Hossain, D. M., Banerjee, S., Das, K., Sa, G. and Das, T.  Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. Carcinogenesis. 2010.  31, 259-268. [PubMed]
3. Das, T., Sa, G., Saha, B. and Das, K.  Multifocal signal modulation therapy of cancer: ancient weapon, modern targets. Molecular and Cellular Biochemistry. 2010.  336, 85-95. [PubMed]
4. Chattopadhyay, S., Bhattacharyya, S., Saha, B., Chakraborty, J., Mohanty, S., Sakib, H., Banerjee, S., Das, K., Sa, G. and Das, T.  Tumor-shed PGE(2) impairs IL2Rgammac-signaling to inhibit CD4 T cell survival: regulation by theaflavins. PloS One. 2009.  4, e7382. [PubMed]
5. Chatterjee, S., Mookerjee, A., Basu, J. M., Chakraborty, P., Ganguly, A., Adhikary, A., Mukhopadhyay, D., Ganguli, S., Banerjee, R., Ashraf, M., Biswas, J., Das, P. K., Sa, G., Chatterjee, M., Das, T. and Choudhuri, S. K.  A novel copper chelate modulates tumor associated macrophages to promote anti-tumor response of T cells. PloS One. 2009.  4, e7048. [PubMed]
6. Sa, G., Das, T., Moon, C., Hilston, C. M., Rayman, P. A., Rini, B. I., Tannenbaum, C. S. and Finke, J. H.  GD3, an overexpressed tumor-derived ganglioside, mediates the apoptosis of activated but not resting T cells. Cancer Research. 2009.  69, 3095-3104. [PubMed]
7. Das, T., Sa, G., Paszkiewicz-Kozik, E., Hilston, C., Molto, L., Rayman, P., Kudo, D., Biswas, K., Bukowski, R. M., Finke, J. H. and Tannenbaum, C. S.  Renal cell carcinoma tumors induce T cell apoptosis through receptor-dependent and receptor-independent pathways. Journal of Immunology. 2008.  180, 4687-4696. [PubMed]
8. Sa, G. and Das, T.  Anti cancer effects of curcumin: cycle of life and death. Cell Division. 2008.  3, 14. [PubMed]
9. Bhattacharyya, A., Mandal, D., Lahiry, L., Bhattacharyya, S., Chattopadhyay, S., Ghosh, U. K., Sa, G. and Das, T.  Black tea-induced amelioration of hepatic oxidative stress through antioxidative activity in EAC-bearing mice. Journal of Environmental Pathology, Toxicology and Oncology. 2007. 26, 245-254. [PubMed]
10. Bhattacharyya, S., Mandal, D., Saha, B., Sen, G. S., Das, T. and Sa, G.  Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. The Journal of Biological Chemistry. 2007.  282, 15954-15964. [PubMed]
11. Mandal, D., Bhattacharyya, S., Lahiry, L., Chattopadhyay, S., Sa, G. and Das, T.  Black tea-induced decrease in IL-10 and TGF-beta of tumor cells promotes Th1/Tc1 response in tumor bearer. Nutrition and Cancer. 2007.  58, 213-221. [PubMed]
12. Raval, G., Biswas, S., Rayman, P., Biswas, K., Sa, G., Ghosh, S., Thornton, M., Hilston, C., Das, T., Bukowski, R., Finke, J. and Tannenbaum, C. S.  TNF-alpha induction of GM2 expression on renal cell carcinomas promotes T cell dysfunction. Journal of Immunology. 2007.  178, 6642-6652. [PubMed]
13. Dasgupta, R., Saha, I., Pal, S., Bhattacharyya, A., Sa, G., Nag, T. C., Das, T. and Maiti, B. R.  Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice. Toxicology. 2006.  227, 94-104. [PubMed]
14. Biswas, K., Richmond, A., Rayman, P., Biswas, S., Thornton, M., Sa, G., Das, T., Zhang, R., Chahlavi, A., Tannenbaum, C. S., Novick, A., Bukowski, R. and Finke, J. H.  GM2 expression in renal cell carcinoma: potential role in tumor-induced T-cell dysfunction. Cancer Research. 2006.  66, 6816-6825. [PubMed]
15. Mookerjee, A., Mookerjee, B., Dutta, P., Majumder, S., Bhattacharyya, S., Biswas, J., Pal, S., Mukherjee, P., Raha, S., Baral, R. N., Das, T., Efferth, T., Sa, G., Roy, S. and Choudhuri, S. K.  Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis. Clinical Cancer Research. 2006.  12, 4339-4349. [PubMed]
16. Choudhuri, T., Pal, S., Das, T. and Sa, G.  Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner. The Journal of Biological Chemistry. 2005.  280, 20059-20068. [PubMed]
17. Sa, G., Guo, Y. and Stacey, D. W.  The regulation of S phase initiation by p27Kip1 in NIH3T3 cells. Cell Cycle. 2005.  4, 618-627. [PubMed]
18. Bhattacharyya, A., Lahiry, L., Mandal, D., Sa, G. and Das, T.  Black tea induces tumor cell apoptosis by Bax translocation, loss in mitochondrial transmembrane potential, cytochrome c release and caspase activation. International Journal of Cancer. 2005.  117, 308-315. [PubMed]
19. Mandal, D., Lahiry, L., Bhattacharyya, A., Bhattacharyya, S., Sa, G. and Das, T.  Tumor-induced thymic involution via inhibition of IL-7R alpha and its JAK-STAT signaling pathway: protection by black tea. International Immunopharmacology. 2006.  6, 433-444. [PubMed]
20. Pal, S., Bhattacharyya, S., Choudhuri, T., Datta, G. K., Das, T. and Sa, G.  Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detection and Prevention. 2005.  29, 470-478. [PubMed]
21. Mandal, D., Bhattacharyya, A., Lahiry, L., Choudhuri, T., Sa, G. and Das, T.  Failure in peripheral immuno-surveillance due to thymic atrophy: importance of thymocyte maturation and apoptosis in adult tumor-bearer. Life Sciences. 2005.  77, 2703-2716. [PubMed]
22. Mandal, D., Lahiry, L., Bhattacharyya, A., Chattopadhyay, S., Siddiqi, M., Sa, G. and Das, T.  Black tea protects thymocytes in tumor-bearing animals by differential regulation of intracellular ROS in tumor cells and thymocytes. Journal of Environmental Pathology, Toxicology and Oncology. 2005.  24, 91-104. [PubMed]
23. Bandyopadhyay, S., Bhattacharyya, A., Mallick, A., Sen, A. K., Tripathi, G., Das, T., Sa, G., Bhattacharya, D. K. and Mandal, C.  Over-expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia. International Immunology. 2005.  17, 177-191. [PubMed]
24. Bhattacharyya, A., Mandal, D., Lahiry, L., Sa, G. and Das, T.  Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio. Cancer Letters. 2004.  209, 147-154. [PubMed]
25. Bhattacharyya, A., Choudhuri, T., Pal, S., Chattopadhyay, S., K, D., Sa, G. and Das, T.  Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell. Carcinogenesis. 2003.  24, 75-80. [PubMed]
26. Ghosh, S., Bhattacharyya, S., Sirkar, M., Sa, G. S., Das, T., Majumdar, D., Roy, S. and Majumdar, S.  Leishmania donovani suppresses activated protein 1 and NF-kappaB activation in host macrophages via ceramide generation: involvement of extracellular signal-regulated kinase. Infection and Immunity. 2002.  70, 6828-6838. [PubMed]
27. Choudhuri, T., Pal, S., Agwarwal, M. L., Das, T. and Sa, G.  Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Letters. 2002.  512, 334-340. [PubMed]
28. Chattopadhyay, S., Das, T., Sa, G. and Ray, P. K.  Protein A-activated macrophages induce apoptosis in Ehrlich's ascites carcinoma through a nitric oxide-dependent pathway. Apoptosis. 2002.  7, 49-57. [PubMed]
29. Pal, S., Choudhuri, T., Chattopadhyay, S., Bhattacharya, A., Datta, G. K., Das, T. and Sa, G.  Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochemical and Biophysical Research Communications. 2001.  288, 658-665. [PubMed]
30. Ghosh, A. K., Jana, S., Das, T., Sa, G., Mandal, N. and Ray, P. K.  Protection by protein A of apoptotic cell death caused by anti-AIDS drug zidovudine. Biochemical and Biophysical Research Communications. 1999.  264, 601-604. [PubMed]
31. Das, T., Sa, G. and Ray, P. K.  Mechanisms of protein A superantigen-induced signal transduction for proliferation of mouse B cell. Immunology Letters. 1999.  70, 43-51. [PubMed]
32. Das, T., Sa, G., Sinha, P. and Ray, P. K.  Induction of cell proliferation and apoptosis: dependence on the dose of the inducer. Biochemical and Biophysical Research Communications. 1999.  260, 105-110. [PubMed]
33. Ghosh, A. K., Jana, S., Das, T., Sa, G., Mandal, N. and Ray, P. K.  Protection by protein A of apoptotic cell death caused by anti-AIDS drug zidovudine. Biochemical and Biophysical Research Communications. 1999.  264, 601-604. [PubMed]
34. Sinha, P., Ghosh, A. K., Das, T., Sa, G. and Ray, P. K.  Protein A of Staphylococcus aureus evokes Th1 type response in mice. Immunology Letters. 1999.  67, 157-165. [PubMed]
35. Murugesan, G., Sa, G. and Fox, P. L.  High-density lipoprotein stimulates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor. Circulation Research. 1994.  74, 1149-1156. [PubMed]
36. Bandyopadhyay, A. K., Das, T., Sa, G. and Mukherjea, M.  Effect of fatty acid binding proteins on developing human placental malate dehydrogenase activity. Indian Journal of Experimental Biology. 1994.  32, 800-803. [PubMed]
37. Sa, G., Das, T. and Mukherjea, M.  Characterization and binding properties of human fetal lung fatty acid-binding proteins. Molecular and Cellular Biochemistry. 1993.  129, 67-75. [PubMed]
38. Das, T., Sa, G. and Mukherjea, M.  Characterization of cardiac fatty-acid-binding protein from human placenta. Comparison with placenta hepatic types. European Journal of Biochemistry. 1993.  211, 725-730. [PubMed]
39. Sa, G., Das, T. and Mukherjea, M.  Purification and characterization of fatty acid-binding proteins from human fetal lung. Experimental Lung Research. 1989.  15, 619-634. [PubMed]
40. Das, T., Sa, G. and Mukherjea, M.  Human fetal liver fatty acid binding proteins. Role on glucose-6-phosphate dehydrogenase activity. Biochimica et Biophysica Acta. 1989.  1002, 164-172. [PubMed]
41. Das, T., Sa, G. and Mukherjea, M.  Purification and characterization of fatty acid-binding protein from human placenta. Lipids. 1988.  23, 528-533. [PubMed]
42. Hossain, D.M.S., Bhattacharyya, S., Das, T. and Sa G. Curcumin: The multi-targeted therapy for cancer regression. Frontiers in Biosciences. 2010.
43. Sa, G., Das, T., Roy, P., Banerjee, S. and Chakraborty, J. Oncogenes as molecular target for curcumin-induced cancer cell apoptosis. Prospective in Cytology and Genetics. 2010. 14.
44. Mohanty, S., Adhikary, A., Chakrabarty, S., Sa, G. and Das, T. Operation ‘p53 Hunt’ to combat cancer: Theaflavins in action.  Frontiers in Biosciences. 2010.
45. Das, T., Sa, G., Saha, S., Mukherjee, S., Mazumdar, M. and Mukherjee, S. p53, a tumor suppressor at the crossroads of the oncogenic networks in cancer: Targeting the guardian of the genome. Prospective in Cytology and Genetics. 2010. 14.
46. Bhattacharyya, S., Hossain, D.Md.S., Mohanty, S., Sen, G.S., Chattopadhyay, S., Banerjee, S., Chakraborty, J., Das, K., Sarkar, D., Das, T. and Sa, G. Curcumin reverses T cell‐mediated adaptive immune dysfunctions in tumor‐bearing host. Cellular and Molecular Immunology. 2010. 7, 306-315.
47. Sa, G., Das, T., Banerjee, S. and Chakraborty, J. Curcumin: From exotic spice to modern anticancer drug. AA J Med Sci. 2010. 3, 21-37.
48. Lahiry, L., Saha, B., Chakraborty, J., Bhattacharyya, S., Chattopadhyay, S., Choudhuri, T., Mandal, D., Bhattacharyya, A., Sa, G. and Das, T. Contribution of p53-mediated transcription-dependent pathway in mammary epithelial carcinoma cell apoptosis by theaflavins. Apoptosis. 2008. 13, 771-81.
49. Das, T., Sa, G., Hilston, C., Kudo, D., Rayman, P., Biswas, K., Molto, L., Bukowski, R., Rini, B., Finke, J.H. and Tannenbaum, C. GM1 and TNFa, overexpressed in renal cell carcinoma, synergize to induce T cell apoptosis. Cancer Research. 68, 2014-23.
50. Das, T., Sa, G., Chattopadhyay, S. and Saha, B. Black tea: The Future Panacea for Cancer. AA J Med Sci. 2008. 1, 70-83.
51. Bhattacharyya, S., Mandal, D., Sen, G.S., Pal, S., Banerjee, S., Lahiry, L., Finke, J.H., Tannenbum, C.S., Das, T. and Sa, G. Tumor-induced oxidative stress perturbs NFkB activity augmenting TNFa-mediated T cell death: Protection by curcumin. Cancer Research. 2007. 67, 362-70.
52. Naha, N., Sa, G., Ganesan, V., Bhar, R. and Chowdhury, A.R. Is occupational lead exposure detrimental to human spermatozoa? A question of recent concern. JCMS. 2005. 2, 105-110.
53. Sa, G. and Stacey, D.W. P27 expression is regulated by separate signaling pathways, down­stream of Ras, in each cell cycle phase. Experimental Cell Research. 2004. 300, 427-439.
54. Mandal, D., Lahiry, L., Bhattacharyya, A., Sa, G. and Das, T. Pharmacotherapeutics of tea: Proposed strategies and pharmacological studies. International Journal of Tea Science. 2004. 3, 261-272.
55. Bhattacharyya, A., Sa, G., Das, T. and Siddiqi, M. Black tea-induced cellular survival: Evidence for reduced toxicity and enhanced immunity in mice under stress. International Journal of Tea Science. 2003. 2, 34-39.
56. Sa, G., Hitomi, M., Harwalkar, J., Stacey, A., Chen, G., and Stacey, D. Ras is active through­out the cell cycle, but is able to induce cyclin D1 only during G2 phase. Cell Cycle. 2003. 50-58.
57. Das, T., Sa, G., Chattopadhyay, S. and Ray, P.K. Protein A-induced apoptosis of cancer cells is affected by soluble immune mediators.  Cancer Immunology and Immunotherapy. 2002. 51, 376-380.
58. Das, T., Sa, G., Subbulakshmi, V., Subramaniam, S., Sen, P.C., Biswas, S. and Ray, P.K. Protein A-acti­vated rat spleenic lymphocyte proliferation involves tyrosine kinase - phospholipase C - protein kinase C pathway. Immunopharmacology and Immunotoxicology. 2000. 22, 75-90.
59. Sa, G. and Das, T. Basic FGF  stimulates phospholipase A2, phospholipase C-g1 and phos­pholipase D through distinguishable signaling mechanisms. Journal of Molecular and Cellular Biochemistry. 1999. 198, 19-30.
60. Ghosh, A.K., Sinha, P., Das, T., Sa, G. and Ray, P.K. S. aureus super­antigen Protein A expand CD4+/CD19+/CD34+ cells in mice- a potential immunorestorer. Biochem. Biophys. Res. Commun. 1999. 256, 142-146.
61. Goenka, S., Das, T., Sa, G. and Ray, P.K. Protein A induces NO produc­tion: Involvement of tyrosine kinase, phospholipae C and Protein kinase C. Biochem. Biophys. Res. Commun. 1998. 250, 425-429.
62. Sa, G., Murugesan, G., Jaye, M., Ivashenko, Y. and Fox, P.L. Activation of cytosolic phos­pho­lipase A2 by basic fibroblast growth factor via a p42 mito­gen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. Journal of Biological Chemistry. 1995. 270, 2360-2300.
63. Bandhopadhyay, A.K., Das, T., Sa, G. and Mukherjea, M. Relationship between glycerol 3 phos­phate dehydrogenase, fatty acid synthase and FABP of developing human placenta. Journal of Biosciences. 1995. 20, 141-150.
64. Sa, G. and Fox, P.L. Basic fibroblast growth factor-stimulated endothelial cell move­ment is mediated by a pertussis toxin-sensitive phospholipase A2 activity. Journal of Biological Chemistry. 1994. 269, 3219-3225.
65. Fox, P.L., Sa, G., Dobrowolski, S.F. and Stacey, D.W. The regulation of endothelial cell motility by p21ras. Oncogene. 1994. 9, 3519-3526.
66. Sa, G. and Fox, P.L. Basic fibroblast growth factor-mediated migration and proliferation of endothelial cells are distinguished by pertussis toxin. FASEB Journal. 1993. 7, A1-A2.
67. Fox, P.L., Chisolm, G.M., Murugesan, G. and Sa, G. Regulation of endothelial cell migra­tion by plasma lipoproteins. Annual Review of Biomedical Engineering. 1993. 21, 1-31.
68. Sa, G., Das, T. and Mukherjea, M. The evaluation of lung maturity by leci­thin, L/S and PG/PI ratios in human fetus. Med Sci Res. 1993. 21, 365-366.
69. Ghosh, P.K., Das, T., Sa, G. and Mukherjea M. Gestational variation in the fluid­ity of human placental brush border membrane: Assessed by lyposomal transfer study. Med Sci Res. 1992. 20, 705-706.
70. Mukhopadhyay, D., Das, T., Sa, G., Ghosh, P.K.and Mukherjea, M. Isolation of fatty acid binding protein from developing human fetal brain. Med Sci Res. 1992. 20, 641-642.
71. Das, T., Sa, G., Bandhopadhyay, A.K. and Mukherjea, M. Relationship between fatty acid bind­ing proteins, acetyl CoA formation and fatty acid synthesis in deve­loping human placenta. Journal of Biosciences. 1991. 16, 235-242.
72. Sa, G., Chatterjee, M., Das, P.K. and Nandy, A. Perception of biotechnology amongst Indian biologists. Indian Biologist. 1991. 28, 53-57. 
73. Chatterjee, M., Sa, G., Datta, A.G., Bhaduri, A.N., Das, P.K. and Nandy, A. Perception of biotech­nology amongst non-biologists in India. Everymans Science. 1991. 26, 48-50.
74. Sa, G., Das, T. and Mukherjea, M. Relationship between fatty acid synthesis, trans­port and total lipid content during human fetal lung development. Indian Journal of Biochemistry and Biophysics. 1990. 27, 43-47.

 


 
 
Education 
::
M.Sc. in Biochemistry, University of Calcutta, Calcutta, India
::
Ph.D. in Biochemistry, University of Calcutta, Calcutta, India
Member
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Editorial board member- International Journal of Cancer Research
::
Journal of Pharmacology and Toxicology
::
Asian Journal Biochemistry
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Asian Journal of Cell Biology
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Associate Editor-Head and Face Medicine
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Guest Editor-American Journal of Immunology
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.