INCREDB ID : 203
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Murali Dharan Bashyam, Ph.D.
Head 
 
Centre for DNA Fingerprinting and Diagnostics
Molecular Oncology Lab
Bldg. 7, Gruhakalpa, 5-4-399 / B, Nampally
Hyderabad - 500 001   
Andhra Pradesh   
 
E-mail: bashyam@cdfd.org.in
Phone: +91-40-24749383
Fax: +91-40-24749448
 
URL: http://www.cdfd.org.in/labpages/murali_bashyam.html
 
Positions Held:
Position Affiliation Time Period
Visiting Fellow Stanford University School of Medicine, California, USA
Post Doctoral Fellowship National Institute of Immunology, New Delhi, India
 
Area of Specialization:
Molecular Biology
Oncology
Research Summary:
Molecular characterization of sporadic colorectal cancer in the young from India
Identification of novel ESCC genes by using a combination of array based CGH and gene expression microarrays
Identification and characterization of pancreatic cancer genes located within novel localized copy number alterations
Molecular studies on genetic disorders
 
Publications:

1

Delma CR, Somasundaram ST, Srinivasan GP, Khursheed M, Bashyam MD, Aravindan N: Fucoidan from Turbinaria conoides: a multifaceted 'deliverable' to combat pancreatic cancer progression. International journal of biological macromolecules 2015, 74:447-457.

2

Bashyam MD, Kotapalli V, Raman R, Chaudhary AK, Yadav BK, Gowrishankar S, Uppin SG, Kongara R, Sastry RA, Vamsy Met al: Evidence for presence of mismatch repair gene expression positive Lynch syndrome cases in India. Molecular carcinogenesis 2015, 54(12):1807-1814.

3

 Adduri,R.S.R., Katamoni,R.,  Pandilla, R., Madanaa, S.N., Paripati, A.K., Kotapalli, V., Bashyam, M.D., TP53 Pro72 allele is enriched in oral tongue cancer and frequently mutated in esophageal cancer in India. Plos One, 2014, 9:e114002.

4

Bashyam, M.D., Kotapalli, V., Raman, R., Chaudhary, A., Yadav, B., Gowrishankar, S., Uppin, S., Kongara, R., Sastry, Vamsy, M., Patanaik, S., Rao, S., Dsouza Shoba, Desai, D., Tester Ashavaid: Evidence for presence of Mismatch Repair gene expression positive Lynch syndrome cases in India. Mol Carcinogenesis, 2014, 54(12):1807-14.

5

Adduri,R.S.R., Kotapalli , V., Gupta, N.A., Gowrishankar, S., Srinivasulu, M., Ali, M.M., Rao, S., Uppin, S., Nayak, U. M., Dhagam, S., Chigurupati, M.V., and  Bashyam, M.D.: P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue. BMC Clinical Pathology, 2014, 14:37.

6

Bashyam, M.D., Chaudhary, A.K., Kiran, M., Reddy, V., Nagarajaram, H.A., Dalal, A.,  Bashyam, A., Suri, D., Gupta, A., Gupta, N., Kabra, M., Puri, R., RadhaRamaDevi, Kapoor, S., Danda, S., Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation. Clin Genet,2014; 86:530-538.

7

Ratheesh R, Viswakalyan K, Mohana V, Sujit CP, Mukta S and Bashyam, M.D.: A positive family history of cancer or lifestyle factors may not explain the high incidence of early-onset CRC in India. Colorectal cancer, 2014; 3:409-416.

8

 Raman, R., Kotapalli, V.,  Adduri, R., Gowrishankar, S., Bashyam, L., Chaudhary, A., Vamsy, M., Patnaik, S., Srinivasulu, M., Sastry, R., Rao, S., Vasala, A., Kalidindi, N.R., Pollack, J., Murthy, S.,  Bashyam, M.D.: Evidence for possible non-canonical pathway(s) driven early-onset colorectal cancer in India, Molecular carcinogenesis, 2014; 53:E181.E186.

9

Bashyam, M.D., Chaudhary, A.K., Sinha, M., Nagarajaram, H.A., Radha RamaDevi, Ranganath, P., Dalal, A., Bashyam, L.,  Gupta, N., Kabra, M., Muranjan, M., Puri, R., Verma, I. C., Nampoothiri, S., Kadandale, J.S., Splice, insertion-deletion and nonsense mutations that perturb the Phenylalanine hydroxylase transcript cause Phenylketonuria in India. J Cell Biochem, 2014, 115:566-574. 

10

Raman, R., Kongara, R., Kotapalli, V.,  ­Gowrishankar, S., Sastry, R.A., Nagari, B.,­Bashyam,  M.D.: Pathological stage significantly predicts survival in colorectal cancer patients: a study from two tertiary care centers in India. Colorectal cancer 3(3), 265-275 (2014).

11

Khursheed, Md., and ­Bashyam,  M.D.:  Apico-basal polarity complex and cancer. J Biosciences 2014; 39:145-155.

12

­Bashyam,  M.D. and Raman, R.: Molecular origins of colon and rectal cancer: not a Wnt-Wnt situation.Current colorectal cancer reports. 2013; 9:365-371.

13

Pandilla, R., Kotapalli, V., Gowrishankar,  S., Chigurupati, M.V., Patnaik, S., Uppin, S., Rao,  S., Kalidindi, N.R., Regulagadda, S., Sundaram, C., Srinivasulu, M., Vasala, A.,­Bashyam,  M.D.: Distinct genetic aberrations in esophageal adeno and squamous carcinoma. Eur J Clin Invest; 2013; 43 (12): 1233-1239

14

Kavela, S., Shinde, S.R., Ratheesh, R., Viswakalyan, K., ­Bashyam,  M.D., Gowrishankar, S., Vamsy, M., Pattnaik, S., Rao, S., Sastry, R., Srinivasulu, M.,  Chen, J., Reddy, M.S. PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer research 2013; 73:205-214.

15

Muranjan M, Agarwal S, Lahiri K, Bashyam M.D.: Novel biochemical abnormalities and genotype in farber disease.Indian Pediatr. 2012 Apr 8; 49(4):320-2.

16

Bashyam, M.D., Chaudhary, A., Manjari, Nagarajaram, H.A., Radha A., Rama Devi, Bashyam, L., Reddy, C., Dalal, A.,:Molecular genetic analysis of MSUD from India reveals mutations causing altered protein truncation affecting the C-termini of E1α and E1β. Journal of Cellular Biochemistry 2012; 113:3122-3132.

17

M D Bashyam, A K Chaudhary, E C Reddy, V Reddy, V Acharya, H A Nagarajaram, A R R Devi, L Bashyam, A B Dalal, N Gupta, M Kabra, M Agarwal, S R Phadke, R Tainwala, R Kumar, S V Hariharan. A founder ectodysplasin A receptor (EDAR) founder mutation results in a high frequency of the autosomal recessive form of Hypohidrotic Ectodermal Dysplasia in India. Br J Dermatol. 2012; 166:819-829.

18

AH Shain, CP Giacomini, K Matsukuma, CA Karikari, MD Bashyam, M Hidalgo, A Maitra, JR Pollack. Convergent structural alterations define SWI/SNF chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci, USA. 2012, 109:E252-E259

19

Kwei KA, Shain AH, Bair R, Montgomery K, Karikari CA, van de Rijn M, Hidalgo M, Maitra A, Bashyam MD, Pollack JR. SMURF1 Amplification Promotes Invasiveness in Pancreatic Cancer. PLoS One 2011;6(8):e23924.

20

Bashyam, M.D., Purushotham, G., Chaudhary, A.K., Rao, M., Acharya, V., Mohammad, T., Nagarajaram, H., Hariram, V., Narasimhan, C., : A low prevalence of MYH7/MYBPC3 mutations among Familial Hypertrophic Cardiomyopathy patients in India. Mol Cell Biochem2012, 360:373-382.

21

RamaDevi, A. R., Reddy, E. C., Ranjan, S. and Bashyam, M. D.  Molecular genetic analysis of patients from India with hypohidrotic ectodermal dysplasia reveals novel mutations in the EDA and EDAR genes. The British Journal of Dermatology. 2008.  158, 163-167. [PubMed]

22

Yabaluri, N. and Bashyam, M. D.  Hormonal regulation of gluconeogenic gene transcription in the liver. Journal of Biosciences. 2010.  35, 473-484. [PubMed]

23

Purushotham, G., Madhumohan, K., Anwaruddin, M., Nagarajaram, H., Hariram, V., Narasimhan, C. and Bashyam, M. D.  The MYH7 p.R787H mutation causes hypertrophic cardiomyopathy in two unrelated families. Experimental and Clinical Cardiology. 2010.  15, e1-4. [PubMed]

24

Bashyam, M. D., Chaudhary, A. K., Reddy, E. C., Devi, A. R., Savithri, G. R., Ratheesh, R., Bashyam, L., Mahesh, E., Sen, D., Puri, R., Verma, I. C., Nampoothiri, S., Vaidyanathan, S., Chandrashekar, M. D. and Kantheti, P.  Phenylalanine hydroxylase gene mutations in phenylketonuria patients from India: identification of novel mutations that affect PAH RNA. Molecular Genetics and Metabolism. 2010.  100, 96-99. [PubMed]

25

Angalena, R., Prabitha, K. N., Chaudhary, A. K., Bashyam, M. D., Jain, S. and Dalal, A. B.  A novel homozygous point mutation at codon 82 (HBB:c.247A > T) in the beta-globin gene leads to thalassemia major. International Journal of Laboratory Hematology. 2010.  32, 548-549. [PubMed]

26

Bashyam M. D.  Nonsense-mediated decay: linking a basic cellular process to human disease. Expert Review of Molecular Diagnostics. 2009.  9, 299-303. [PubMed]

27

Kumar, M. S., Ramachandran, A., Hasnain, S. E. and Bashyam, M. D.  Octamer and heat shock elements regulate transcription from the AcMNPV polyhedrin gene promoter. Archives of Virology. 2009.  154, 445-456. [PubMed]

28

Bashyam M. D.  Studies on nonsense mediated decay reveal novel therapeutic options for genetic diseases. Recent Patents On DNA & Gene Sequences. 2009.  3, 7-15. [PubMed]

29

Kwei, K. A., Bashyam, M. D., Kao, J., Ratheesh, R., Reddy, E. C., Kim, Y. H., Montgomery, K., Giacomini, C. P., Choi, Y. L., Chatterjee, S., Karikari, C. A., Salari, K., Wang, P., Hernandez-Boussard, T., Swarnalata, G., van, d. e., Maitra, A. and Pollack, J. R.  Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLoS Genetics. 2008.  4, e1000081. [PubMed]

30

RamaDevi, A. R., Reddy, E. C., Ranjan, S. and Bashyam, M. D.  Molecular genetic analysis of patients from India with hypohidrotic ectodermal dysplasia reveals novel mutations in the EDA and EDAR genes. The British Journal of Dermatology. 2008.  158, 163-167. [PubMed]

31

Bashyam, M. D., Savithri, G. R., Gopikrishna, M. and Narasimhan, C.  A p.R870H mutation in the beta-cardiac myosin heavy chain 7 gene causes familial hypertrophic cardiomyopathy in several members of an Indian family. The Canadian Journal of Cardiology. 2007.  23, 788-790. [PubMed]

32

Bashyam, M. D., Bair, R., Kim, Y. H., Wang, P., Hernandez-Boussard, T., Karikari, C. A., Tibshirani, R., Maitra, A. and Pollack, J. R.  Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer. Neoplasia. 2005.  7, 556-562. [PubMed]

33

Bashyam, M. D. and Hasnain, S. E.  The extracytoplasmic function sigma factors: role in bacterial pathogenesis. Infection, Genetics and Evolution. 2004.  4, 301-308. [PubMed]

34

Bashyam, M. D., Bashyam, L., Savithri, G. R., Gopikrishna, M., Sangal, V. and Devi, A. R.  Molecular genetic analyses of beta-thalassemia in South India reveals rare mutations in the beta-globin gene. Journal of Human Genetics. 2004.  49, 408-413. [PubMed]

35

Viswanathan, P., Venkaiah, B., Kumar, M. S., Rasheedi, S., Vrati, S., Bashyam, M. D. and Hasnain, S. E.  The homologous region sequence (hr1) of Autographa californica multinucleocapsid polyhedrosis virus can enhance transcription from non-baculoviral promoters in mammalian cells. The Journal of Biological Chemistry. 2003.  278, 52564-52571. [PubMed]

36

Bashyam, M. D. and Hasnain, S. E.  The human genome sequence: impact on health care. The Indian Journal of Medical Research. 2003.  117, 43-65. [PubMed]

37

Bashyam, M. D., Savithri, G. R., Kumar, M. S., Narasimhan, C. and Nallari, P.  Molecular genetics of familial hypertrophic cardiomyopathy (FHC). Journal of Human Genetics. 2003.  48, 55-64. [PubMed]

38

Bashyam M. D.  Understanding cancer metastasis: an urgent need for using differential gene expression analysis. Cancer. 2002.  94, 1821-1829. [PubMed]

39

Ramachandran, A., Jain, A., Arora, P., Bashyam, M. D., Chatterjee, U., Ghosh, S., Parnaik, V. K. and Hasnain, S. E.  Novel Sp family-like transcription factors are present in adult insect cells and are involved in transcription from the polyhedrin gene initiator promoter. The Journal of Biological Chemistry. 2001.  276, 23440-23449. [PubMed]

40

Bashyam, M. D. and Tyagi, A. K.  Identification and analysis of "extended -10" promoters from mycobacteria. Journal of Bacteriology. 1998.  180, 2568-2573. [PubMed]

41

Bashyam, M. D., Kaushal, D., Dasgupta, S. K. and Tyagi, A. K.  A study of mycobacterial transcriptional apparatus: identification of novel features in promoter elements. Journal of Bacteriology. 1996.  178, 4847-4853. [PubMed]

42

Bashyam, M. D. and Tyagi, A.  An efficient and high-yielding method for isolation of RNA from mycobacteria. BioTechniques. 1994.  17, 834-836. [PubMed]

43

Das, G., Bashyam, M. D. and Tyagi, A. K.  Cloning and assessment of mycobacterial promoters by using a plasmid shuttle vector. Journal of Bacteriology. 1993.  175, 5186-5192. [PubMed]

44

Angalena, R., Chaudhary, A., Murali, D., Bashyam, Dalal, A., Hemoglobin D masquerading as Hemoglobin E: An interesting case report. Newsletter of Genetics Chapter of Indian Academy of Pediatrics, 2009, Vol 2, Issue 1.

45

Bashyam M. D.  Studies on nonsense mediated decay reveal novel therapeutic options for genetic diseases. Recent Patents On DNA & Gene Sequences. 2009. 3, 7-15. [PubMed]

46

Murali D Bashyam and R Ratheesh. Genetic instability in colorectal cancer. ICFAI Journal of Biotechnology, 2008, 2:13-26.

47

Devi, A. R., Gopikrishna, M., Ratheesh, R., Savithri, G., Swarnalata, G. and Bashyam, M.  Farber lipogranulomatosis: clinical and molecular genetic analysis reveals a novel mutation in an Indian family. Journal of Human Genetics. 2006. 51, 811-814. [PubMed]

48

RamaDevi, A. R., Reddy, E. C., Ranjan, S. and Bashyam, M. D.  Molecular genetic analysis of patients from India with hypohidrotic ectodermal dysplasia reveals novel mutations in the EDA and EDAR genes. The British Journal of Dermatology. 2008. 158, 163-167. [PubMed]

49

Bashyam, M., D., Prokaryotic Genomes. Book Review, Current Science, 2003, 84:1366-1367.

50

Bashyam, M., D., Microarrays for the Neurosciences : An essential guide. Daniel H. Geschwind and Jeffery P. Gregg (eds.). Book Review, Current Science, 2002, 83:649-650.

51

Ramachandran, A., Bashyam, M., D., Viswanathan, P., Ghosh, S., Kumar, M., S., Hasnain, S., E., The bountiful and baffling baculovirus: The story of polyhedrin transcription. Current Science, 2001,  81:998-1010.

52

Bashyam, M., D., Ghosh, S., Ramachandran, A., Viswanathan, P., Hasnain, S., E. Multiple regulatory circuits for transcription from the polyhedrin gene promoter of the Autographa californica  multiple nucleocapsid nuclear polyhedrosis  virus. Proceeding. Indian National. Science Academy.2000, B66 Nos 2&3 pp 83-96.

53

Bashyam, M. D., Kaushal, D., Dasgupta, S., K. and Tyagi, A., K., A study of the mycobacterial transcriptional apparatus: identification of novel features in promoter elements. Journal of Bacteriology.1996, 178:4847-4853.

 

Book Chapters:
Angalena R, Ajay Chaudhary, Murali D Bashyam, Ashwin Dalal. Hemoglobin D (Iran) masquerading as Hemoglobin E: An interesting case report. Newsletter of Genetics Chapter of Indian Academy of Pediatrics, Vol 2, Issue 1. Jan-Mar 2009.
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Molecular characterization of sporadic colorectal cancer in the young from India Fogarty International Research Collaboration Award, National Institutes of Health, Maryland, USA
Identification of novel esophageal squamous cell carcinoma (ESCC) genes by using a combination of array based CGH and gene expression microarrays Department of Biotechnology, Government of India
Identification and characterization of pancreatic cancer genes located within novel localized copy number alterations Department of Science & Technology, Government of India
Molecular genetic analyses of Familial Hypertrophic Cardiomyopathy in Andhra Pradesh Department of Biotechnology, Government of India
Molecular studies on genetic disorders in Andhra Pradesh

 

 
 
Education 
::
Ph.D. in Biochemistry, Delhi University
Honors and Awards
::
2010, Faculty from developing countries award from American Association for Cancer Research from the laboratory to the clinic, Jordan
::
2009, Awarded the National Cancer Institute, USA Fellowship
::
2008, American Association for Cancer Research National Cancer Institute International investigator opportunity grant
::
2008, Selected as a member of the multidisciplinary young scientist team, by the Indian National Science Academy and Department of Science and Technology, Government of India
::
2008, Fogarty International Research Collaboration Award, Fogarty International Center, National Institutes of Health, USA
::
2006, Indian National Science Academy, Govt of India, travel grant to present abstract at the Cold Spring Harbor Meeting on Mechanisms and Models of Cancer
::
2005, International Cancer Technology Transfer Fellowship of the International Union Against Cancer
::
2005, Sir Dorabji Tata Trust travel award
::
2003, The Overseas Associateship Award of the Department of Biotechnology
::
2001, Young Scientist Award of the Department of Science and Technology
::
2000, Sir Jamsetji Tata Trust Award for training in Microarray Technology at the Memorial Sloan Kettering Cancer Center, New York, USA
::
2000, Sir Dorabji Tata Trust Award for training in Microarray Technology at the Memorial Sloan Kettering Cancer Center, New York, USA
::
1998, Young scientist medal of the Indian National Science Academy
::
1995, Young scientist award of the Association of Microbiologists of India
Member
::
The National Academy of Sciences, Allahabad
  Last modified on : Dec 11, 2015
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